A high pressure in the pulmonary circulation (pulmonary hypertension, PH) complicates several highly prevalent chronic diseases, including left heart failure and chronic thrombo-embolic disease. Pulmonary arterial hypertension (PAH) is a fatally progressive form of PH with characteristic changes in small lung arteries, affecting 1/50.000 humans. Regardless of primary cause, PH almost invariably leads to right heart failure and death.
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